MAPK/ERK and PI3K/AKT signaling pathways are activated in adolescent and adult acute lymphoblastic leukemia

Background: The mitogen‐activated protein kinase (MAPK)/ERK signaling cascade and the phosphoinosytol‐3 phosphate/Akt (PI3K/Akt) pathways are involved in proliferation and differentiation of hematopoietic cells. The frequency of PI3K/Akt and MAPK pathway activation in adult acute lymphoblastic leuke...

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Published in:Cancer reports 2023-12, Vol.6 (12), p.e1912-n/a
Main Authors: Loureiro, Gustavo, Bahia, Daniella M., Lee, Maria Lucia M., Souza, Mair Pedro, Kimura, Eliza Y. S., Rezende, Denise Carvalho, Silva, Marçal Cavalcante de Andrade, Chauffaille, Maria de Lourdes L. F., Yamamoto, Mihoko
Format: Article
Language:English
Subjects:
Adolescent
ALL
Apoptosis
Bone marrow
Cell growth
ERK
Flow cytometry
Glycoproteins
Humans
Investigations
Kinases
Leukemia
MAPK
Medical prognosis
Mitogen-Activated Protein Kinases - metabolism
Original
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation
PI3K/Akt
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction - physiology
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Summary:Background: The mitogen‐activated protein kinase (MAPK)/ERK signaling cascade and the phosphoinosytol‐3 phosphate/Akt (PI3K/Akt) pathways are involved in proliferation and differentiation of hematopoietic cells. The frequency of PI3K/Akt and MAPK pathway activation in adult acute lymphoblastic leukemia (ALL) still need to be elucidated. Aims: To assess the activity and prognostic implications of MAPK/ERK and PI3K/Akt pathways in adult (ALL). Methods We examined 28 precursor‐B‐cell ALL and 6 T‐cell primary ALL samples. Flow cytometry was employed to analyze the expression levels of phosphorylated ERK and phosphorylated Akt. Results Ten out of 15 (67%) ALL fresh samples (7 B‐cell, 3 T‐cell) showed constitutive p‐ERK expression. The p‐ERK mean fluorescent index ratio (MFI (R)) showed a tendency to be higher in ALL than in normal T lymphocytes (1.26 [0.74–3.10] vs. 1.08 [1.02–1.21], respectively [p = .069]) and was significantly lower than in leukemic cell lines (median MFI (R) 3.83 [3.71–5.97] [p 
ISSN:2573-8348
2573-8348
DOI:10.1002/cnr2.1912