Implementation of a self-sampling HPV test for non-responders to cervical cancer screening in Japan: secondary analysis of the ACCESS trial

A self-sampling human papillomavirus (HPV) test could improve the morbidity and mortality of cervical cancer in Japan. However, its effectiveness and feasibility have not been demonstrated sufficiently. Hence, we launched a randomized controlled trial, which is ongoing, and report the results of a s...

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Published in:Scientific reports 2022-08, Vol.12 (1), p.14531-14531, Article 14531
Main Authors: Fujita, Misuzu, Nagashima, Kengo, Shimazu, Minobu, Suzuki, Misae, Tauchi, Ichiro, Sakuma, Miwa, Yamamoto, Setsuko, Hanaoka, Hideki, Shozu, Makio, Tsuruoka, Nobuhide, Kasai, Tokuzo, Hata, Akira
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692/308/174
692/308/2779/777
692/4028/67/1517
692/4028/67/2195
692/4028/67/2322
692/700/478
Cancer screening
Cervical cancer
Cervix
Consent
Human papillomavirus
Humanities and Social Sciences
Medical screening
Morbidity
multidisciplinary
Sampling
Science
Science (multidisciplinary)
Secondary analysis
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creator Fujita, Misuzu
Nagashima, Kengo
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Shozu, Makio
Tsuruoka, Nobuhide
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description A self-sampling human papillomavirus (HPV) test could improve the morbidity and mortality of cervical cancer in Japan. However, its effectiveness and feasibility have not been demonstrated sufficiently. Hence, we launched a randomized controlled trial, which is ongoing, and report the results of a secondary analysis. To ensure autonomous participation with a minimum selection bias, opt-out consent was obtained from women who met the inclusion criteria, and written consent was obtained from those who underwent a self-sampling test. The number of women who met the inclusion criteria was 20,555; 4283 and 1138 opted out before and after the assignment, respectively. Of the 7340 women in the self-sampling arm, 1372 (18.7%) ordered and 1196 (16.3%) underwent the test. Younger women in their 30 s and 40 s tended to undertake the test more frequently than older women in their 50 s ( P for trend 
doi_str_mv 10.1038/s41598-022-18800-w
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subjects 692/308/174
692/308/2779/777
692/4028/67/1517
692/4028/67/2195
692/4028/67/2322
692/700/478
Cancer screening
Cervical cancer
Cervix
Consent
Human papillomavirus
Humanities and Social Sciences
Medical screening
Morbidity
multidisciplinary
Sampling
Science
Science (multidisciplinary)
Secondary analysis
title Implementation of a self-sampling HPV test for non-responders to cervical cancer screening in Japan: secondary analysis of the ACCESS trial
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