Essential nutrients and cerebral small vessel diseases: a two-sample Mendelian randomization study

Previous studies have suggested a potential association between nutrients and cerebral small vessel disease (CSVD), but this association has not been fully addressed. We intended to clarify the causal associations between four categories of essential nutrients (amino acids, polyunsaturated fatty aci...

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Published in:Frontiers in nutrition (Lausanne) 2023-06, Vol.10, p.1172587-1172587
Main Authors: Li, Jiayi, Xia, Kailin, Wang, Zhengrui, Liu, Yanru, Tong, Yicheng, Wang, Yuwei, Zhou, Yumou, Zhang, Linjing, Tang, Lu, Fan, Dongsheng, Yang, Qiong
Format: Article
Language:English
Subjects:
cerebral small vessel disease
intracerebral hemorrhage
Mendelian randomization
nutrient
Nutrition
small vessel stroke
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Summary:Previous studies have suggested a potential association between nutrients and cerebral small vessel disease (CSVD), but this association has not been fully addressed. We intended to clarify the causal associations between four categories of essential nutrients (amino acids, polyunsaturated fatty acids, minerals and vitamins) and two acute manifestations of CSVD (intracerebral hemorrhage and small vessel stroke) using two-sample Mendelian randomization (MR) analysis. We obtained European-based large-scale genome-wide association studies (GWASs) related to CSVD (6,255 cases and 233,058 controls) and nutrient concentrations. Causality evaluation mainly included the results of the inverse variance-weighted (IVW) method. The simple median method, the weighted median method and the MR-Egger method were adopted for sensitivity analyses. For ICH or SVS, increased levels of phenylalanine (OR = 1.188,  
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2023.1172587