Association Between Platelet Indices and Preoperative Deep Vein Thrombosis in Elderly Patients Undergoing Total Joint Arthroplasty: A Retrospective Study

• Published in: Clinical and applied thrombosis/hemostasis 2023-01, Vol.29, p.10760296221149699
• Main Authors: Xiong, Xiaojuan, Li, Ting, Yu, Shuang, Cheng, Bo
• Format: Article
• Language: English
• Subjects: Adrenal Cortex Hormones; Aged; Arthroplasty; Blood Platelets; Health risks; Humans; Joint surgery; Mean Platelet Volume; Older people; Original Manuscript; Perioperative care; Platelet Count; Regression analysis; Retrospective Studies; Steroids; Thrombosis; Venous Thrombosis - etiology
• ISSN: 1076-0296; 1938-2723; 1938-2723
• DOI: 10.1177/10760296221149699

To investigate the association between platelet (PLT) indices and preoperative deep vein thrombosis (DVT) in elderly patients undergoing total joint arthroplasty (TJA). A total of 1391 patients were enrolled. We created receiver operator characteristic (ROC) curve using the ratio of PLT indices to DVT before TJA, divided the enrolled patients into groups based on the cut-off value, and then analyzed risk factors for DVT before TJA in the multivariate binary logistic regression analysis. Preoperative DVT occurred in 103 cases. Based on the ROC curve, we determined that the cut-off values for PLT, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) were 202 × 109/L, 11.4 fL, 13.2 fL, 34.6%, and 0.228%. And the areas under the curve were 0.606, 0.605, 0.617, 0.616, and 0.598. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with PLT≥202 × 109/L, MPV≤11.4 fL, PDW≤13.2 fL, P-LCR≤34.6%, and PCT≥0.228% increased by 2.32 (P