Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller?

Tryptophan (Trp) is one of the important essential amino acids and Kynurenine pathway (KP) is the first and rate limiting step of degrading Trp to active metabolites. Recent studies showed that KP metabolites have antimicrobial and immunosuppressive roles. The main controller enzyme of this pathway...

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Bibliographic Details
Published in:Journal of oncological science 2017-07, Vol.3 (2), p.52-56
Main Authors: Bilir, Cemil, Sarisozen, Can
Format: Article
Language:English
Subjects:
Cancer
Indoleamine 2,3-dioxygenase
Kynurenine pathway
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Summary:Tryptophan (Trp) is one of the important essential amino acids and Kynurenine pathway (KP) is the first and rate limiting step of degrading Trp to active metabolites. Recent studies showed that KP metabolites have antimicrobial and immunosuppressive roles. The main controller enzyme of this pathway is indoleamine-2,3-dioxygenase (IDO). IDO is an intracellular monomeric, heme-containing enzyme that controls the Trp breakdown in the KP. In this review, we discuss IDO functions on cancer progression and prognosis, and possible therapeutic aspects of inhibition of IDO on cancer immunotherapy.
ISSN:2452-3364
2452-3364
DOI:10.1016/j.jons.2017.04.001