Protective Effects of Ellagic Acid Against Alcoholic Liver Disease in Mice

Ellagic acid, a natural polyphenolic compound commonly present in vegetables, fruits, nuts, and other edible plants, exerts many pharmacological activities. The present project was designed to explore the hepatoprotective effect of ellagic acid against alcohol-induced liver disease (ALD) and the cor...

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Published in:Frontiers in nutrition (Lausanne) 2021-09, Vol.8, p.744520-744520
Main Authors: Zhao, Liang, Mehmood, Arshad, Soliman, Mohamed Mohamed, Iftikhar, Asra, Iftikhar, Maryam, Aboelenin, Salama Mostafa, Wang, Chengtao
Format: Article
Language:English
Subjects:
alcoholic liver disease
ellagic acid
gut microbiota
inflammation
Nutrition
polyphenolic compound
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Summary:Ellagic acid, a natural polyphenolic compound commonly present in vegetables, fruits, nuts, and other edible plants, exerts many pharmacological activities. The present project was designed to explore the hepatoprotective effect of ellagic acid against alcohol-induced liver disease (ALD) and the correlation among alcohol, oxidative stress, inflammation, and gut microbiota. Fifty percent (v/v) alcohol (10 mL/kg bw daily) was orally administrated for 4 weeks in mice along with ellagic acid (50 and 100 mg/kg bw). Alcohol administration significantly ( p < 0.05) increased the activities of alanine aminotransferase and serum aspartate aminotransferase, levels of triglyceride, low density lipoprotein, free fatty acid, and total cholesterol, and decreased contents of the high-density lipoprotein in model group compared with the control group, which were further improved by ellagic acid (50 or 100 mg/kg bw). Furthermore, daily supplementation of ellagic acid alleviated hepatic antioxidant activities (glutathione peroxidase, catalase, malondialdehyde, superoxide dismutase, and glutathione), proinflammatory cytokines levels (IL-6, IL-1β, and TNF-α), genes expressions ( Tlr4, Myd88, Cd14, Cox2, Nos2 , and Nf κ b1 ), and histopathological features in alcohol-induced liver injured mice. Additionally, results also revealed that ellagic acid supplementation improved alcohol-induced gut microbiota dysbiosis. In conclusion, ellagic acid mitigated oxidative stress, inflammatory response, steatosis, and gut microbiota dysbiosis in ALD mice. Our results suggested that ellagic acid could be applied as an ideal dietary therapy against ALD.
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2021.744520