From genetics to systems biology of stress-related mental disorders

Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these dis...

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Bibliographic Details
Published in:Neurobiology of stress 2021-11, Vol.15, p.100393-100393, Article 100393
Main Authors: Dalvie, Shareefa, Chatzinakos, Chris, Al Zoubi, Obada, Georgiadis, Foivos, Lancashire, Lee, Daskalakis, Nikolaos P.
Format: Article
Language:English
Subjects:
Epigenomics
Genetics
Original
Stress disorders
Systems biology
Transcriptome
Traumatic
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Summary:Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between ∼30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders.
ISSN:2352-2895
2352-2895
DOI:10.1016/j.ynstr.2021.100393