Increased risk of open angle glaucoma in patients with moyamoya disease from a nationwide population-based cohort in Korea

• Published in: Scientific reports 2024-12, Vol.14 (1), p.29992-7, Article 29992
• Main Authors: Kim, Min Seok, Lee, Eun Ji, Lee, Si Un, Kim, Tae-Woo, Park, Sang Jun, Woo, Se Joon, Lee, Jeongwoo, Nam, Seonghee, Joo, Kwangsic
• Format: Article
• Language: English
• Subjects: 692/699/3161; 692/699/375; Adolescent; Adult; Aged; Diagnosis; Female; Glaucoma; Glaucoma, Open-Angle - complications; Glaucoma, Open-Angle - epidemiology; Humanities and Social Sciences; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Moyamoya disease; Moyamoya Disease - complications; Moyamoya Disease - epidemiology; multidisciplinary; Population studies; Proportional Hazards Models; Regression analysis; Republic of Korea - epidemiology; Retrospective Studies; Risk factor; Risk Factors; Science; Science (multidisciplinary); Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-80491-2

This nationwide population-based retrospective cohort study aims to investigate the association between Moyamoya disease (MMD) and open-angle glaucoma (OAG). In this study using the Korean National Health Insurance Service database, a total of 36,432 patients having diagnostic code with MMD between 2002 and 2022, and their age-, sex-matched non-MMD controls ( n  = 346,769) were included. We used a Cox proportional hazard model to determine the association between MMD and subsequent OAG after excluding cases with preexisting diagnosis of MMD for the initial 2-year. Kaplan-Meier survival analyses with log-rank test were performed to compare the incidence probability of OAG based on the MMD diagnosis. Cox regression analysis showed that the diagnosis of MMD was associated with increased risk of subsequent diagnosis of OAG (adjusted HR, 1.26; 95% CI, 1.14–1.38; P