Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy

Non-destructive analysis of chlorpheniramine maleate (CPM), pharmaceutical tablets, and granules was conducted by chemometrics-assisted attenuated total reflectance infrared spectroscopy (ATR-IR). For tablets, an optimum PLSR model with eight latent factors was obtained from area-normalized and stan...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-06, Vol.27 (12), p.3760
Main Authors: Phechkrajang, Chutima, Khongkaew, Putthiporn, Limwikrant, Waree, Jaturanpinyo, Montree
Format: Article
Language:English
Subjects:
Bias
Calibration
Chemometrics
content uniformity
Correlation coefficient
Correlation coefficients
Drug dosages
FT-IR
Granular materials
Infrared analysis
Infrared spectroscopy
Methods
non-destructive analysis
Nondestructive testing
Particle size
Pharmaceutical industry
PLSR
Quality control
Reflectance
Spectrum analysis
Tablets
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Summary:Non-destructive analysis of chlorpheniramine maleate (CPM), pharmaceutical tablets, and granules was conducted by chemometrics-assisted attenuated total reflectance infrared spectroscopy (ATR-IR). For tablets, an optimum PLSR model with eight latent factors was obtained from area-normalized and standard normal variate (SNV) pretreated ATR-IR spectral data with correlation coefficients (R2) of calibration and cross-validation of 0.9716 and 0.9602, respectively. The model capability for the 42 test set samples was proven with R2 between the reference and model prediction values of 0.9632, and a root-mean-square error of prediction (RMSEP) of 1.7786. The successive PLSR model for granules was constructed from SNV and first derivative pretreated ATR-IR spectral data with two latent factors and correlation coefficients (R2) of calibration and cross-validation of 0.9577 and 0.9450, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27123760