T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation

The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective B cell compartment. However, it is unknown whether...

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Bibliographic Details
Published in:Frontiers in immunology 2022-05, Vol.13, p.889564-889564
Main Authors: Betzler, Annika C, Ezić, Jasmin, Abou Kors, Tsima, Hoffmann, Thomas K, Wirth, Thomas, Brunner, Cornelia
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - metabolism
BOB.1/OBF.1
Cell Differentiation
follicular T helper cells
Germinal Center
humoral immunity
Immunology
Lymphocyte Activation
Mice
T cell differentiation
Trans-Activators
Transcription Factors - metabolism
transcriptional co-activator
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Summary:The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective B cell compartment. However, it is unknown whether and how BOB.1/OBF.1 expression in T cells contributes to the GC reaction. To finally clarify this question, we studied the function of BOB.1/OBF.1 in CD4 T and follicular T helper (TFH) cell subpopulations by conditional mutagenesis, in the presence of immunocompetent B lymphocytes. BOB.1/OBF.1 deletion in CD4 T as well as TFH cells resulted in impaired GC formation demonstrating that the impaired GC reaction described for conventional BOB.1/OBF.1-deficient mice cannot exclusively be traced back to the B cell compartment. Furthermore, we show a requirement of BOB.1/OBF.1 for T helper (TH) cell subsets, particularly for TFH cell differentiation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.889564