Marchiafava-Bignami disease: Case presentation and radiological imaging

Marchiafava-Bignami disease (MBD) is a rare vitamin B deficiency classically associated with alcoholism. MBD damages the corpus callosum and presents with nonspecific neurological symptoms. Radiological imaging is critical for diagnosing MBD and commencing subsequent treatment, which often consists...

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Bibliographic Details
Published in:Radiology case reports 2023-11, Vol.18 (11), p.3922-3925
Main Authors: Waack, Andrew, Nandwani, Swamroop, Ranabothu, Meghana, Ranabothu, Akash, Vattipally, Venkatramana
Format: Article
Language:English
Subjects:
Alcohol
Case Report
Centrum semiovale
Corpus callosum
Sandwich sign
Splenium
Thiamine
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Summary:Marchiafava-Bignami disease (MBD) is a rare vitamin B deficiency classically associated with alcoholism. MBD damages the corpus callosum and presents with nonspecific neurological symptoms. Radiological imaging is critical for diagnosing MBD and commencing subsequent treatment, which often consists of vitamin B supplementation. We present a case of MBD in a 56-year-old male with alcohol use disorder, epilepsy, schizophrenia, post-traumatic stress disorder, and cardiovascular risk factors. The patient presented with general neurological symptoms, and there were several potential diagnoses to consider based on the patient's history. Radiological imaging was necessary for diagnosis. This case demonstrates the role radiological imaging plays in the workup of MBD.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2023.08.032