Mechanistic advances in osteoporosis and anti‐osteoporosis therapies

Osteoporosis is a type of bone loss disease characterized by a reduction in bone mass and microarchitectural deterioration of bone tissue. With the intensification of global aging, this disease is now regarded as one of the major public health problems that often leads to unbearable pain, risk of bo...

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Bibliographic Details
Published in:MedComm (2020) 2023-06, Vol.4 (3), p.e244-n/a
Main Authors: Wang, Haiwei, Luo, Yuchuan, Wang, Haisheng, Li, Feifei, Yu, Fanyuan, Ye, Ling
Format: Article
Language:English
Subjects:
anti‐osteoporosis therapies
biomedical mechanism
Osteoporosis
pathogenesis
Review
Reviews
small molecular interventions
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Summary:Osteoporosis is a type of bone loss disease characterized by a reduction in bone mass and microarchitectural deterioration of bone tissue. With the intensification of global aging, this disease is now regarded as one of the major public health problems that often leads to unbearable pain, risk of bone fractures, and even death, causing an enormous burden at both the human and socioeconomic layers. Classic anti‐osteoporosis pharmacological options include anti‐resorptive and anabolic agents, whose ability to improve bone mineral density and resist bone fracture is being gradually confirmed. However, long‐term or high‐frequency use of these drugs may bring some side effects and adverse reactions. Therefore, an increasing number of studies are devoted to finding new pathogenesis or potential therapeutic targets of osteoporosis, and it is of great importance to comprehensively recognize osteoporosis and develop viable and efficient therapeutic approaches. In this study, we systematically reviewed literatures and clinical evidences to both mechanistically and clinically demonstrate the state‐of‐art advances in osteoporosis. This work will endow readers with the mechanistical advances and clinical knowledge of osteoporosis and furthermore present the most updated anti‐osteoporosis therapies. Osteoporosis, a type of bone loss disease, causes enormous burden at both the human and socioeconomic layer. In this study, we systematically reviewed according literatures and clinical evidences to both mechanistically and clinically demonstrate the state‐of‐art advances on osteoporosis, and furthermore present the most updated anti‐osteoporosis therapies.
ISSN:2688-2663
2688-2663
DOI:10.1002/mco2.244