Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats

To investigate the ameliorative effects of (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats were treated orall...

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Bibliographic Details
Published in:Journal of pain research 2020-01, Vol.13, p.261-271
Main Authors: Sudirman, Sabri, Chen, Chun-Kai, Long, Bing-Ting, Chang, Heng-Wei, Tsou, David, Kong, Zwe-Ling
Format: Article
Language:English
Subjects:
Inflammation
Interleukins
medial meniscectomy
Necrosis
Nitric oxide
Nitrogen oxides
obesity
Original Research
Osteoarthritis
Surgery
Triglycerides
triterpene
Tumor necrosis factor
Tumors
Vice presidents (Organizations)
vitellaria paradoxa
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Summary:To investigate the ameliorative effects of (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats were treated orally with three different doses of VP nut extract (111.6, 223.2, and 446.4 mg/kg) for 8 weeks. The VP nut triterpene-rich extract decreased the level of triglycerides and increased high-density lipoprotein-cholesterol. The level of nitric oxide, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α decreased after treatment with VP nut triterpene-rich extract, especially in high-doses. The VP nut triterpene-rich extracts also alleviated swelling in the knee OA, weight-bearing difference, and suppressed cartilage degradation. The nut triterpene-rich extract suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis with an obesity rat model. As such, nut triterpene-rich extract can be used as an alternative for osteoarthritis treatment.
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S228766