Combination versus single-agent as palliative chemotherapy for gastric cancer

Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall surviv...

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Bibliographic Details
Published in:BMC cancer 2020-03, Vol.20 (1), p.167-167, Article 167
Main Authors: Choi, Jin-Hyuk, Choi, Yong Won, Kang, Seok Yun, Jeong, Geum Sook, Lee, Hyun Woo, Jeong, Seong Hyun, Park, Joon Seong, Ahn, Mi Sun, Sheen, Seung Soo
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Analysis
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Cancer metastasis
Cancer therapies
Cancer treatment
Chemotherapy
Combination
Combination drug therapy
Elderly
Elderly patients
Female
Gastric cancer
Histology
Humans
Lymphocyte Count
Lymphocytes
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Neutrophils
Neutrophils - cytology
Operating systems (Software)
Palliation
Palliative Care - methods
Palliative chemotherapy
Patients
Platelet Count
Platelet-to-lymphocyte ratio
Recurrence (Disease)
Retrospective Studies
Single
Stomach cancer
Stomach Neoplasms - blood
Stomach Neoplasms - drug therapy
Studies
Surgery
Survival Analysis
Young Adult
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Description
Summary:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall survival (OS) between CC and single-agent chemotherapy (SC) among these patients, and we analyzed the clinicopathological characteristics affecting outcome including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Although 521 patients (75.8%) underwent CC, SC was more frequently performed in elderly patients (57.6%) and ECOG performance status (PS) 2 or 3 (65.8%) patients (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-6666-1