The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study

The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adiponectin and...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.6434-6, Article 6434
Main Authors: Sakura, Takeshi, Okuno, Senji, Nishio, Eriko, Norimine, Kyoko, Ishimura, Eiji, Yamakawa, Tomoyuki, Shoji, Shigeichi, Inaba, Masaaki
Format: Article
Language:English
Subjects:
692/4019/592/2193
692/4022/1585/104/1586
Abdomen
Adiponectin
Aorta
Arteriosclerosis
Atherosclerosis
Body fat
Body weight
Calcification
Calcification (ectopic)
Diabetes mellitus
Hemodialysis
Humanities and Social Sciences
Kidney transplantation
Leptin
multidisciplinary
Observational studies
Radiography
Regression analysis
Risk factors
Science
Science (multidisciplinary)
Secretion
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Summary:The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adiponectin and leptin to abdominal aortic calcification (AAC). The presence of AAC was evaluated from simple X-ray radiographs of the left lateral abdomen. Serum adiponectin was significantly higher in AAC-positive patients [18.8 (13.0–28.1) μg/mL] than in AAC-negative patients [15.4 (8.9–22.8) μg/mL] (p = 0.03), whereas serum leptin did not differ significantly between the two groups. Multiple logistic regression analysis showed that log adiponectin, but not log leptin, was independently and significantly associated in a positive manner with AAC (odds ratio: 16.31, 95% confidence interval: 1.70–156.41, p = 0.02), after adjustment for age, body weight, percentage body fat, hemodialysis duration, prevalence of diabetes mellitus, and other risk factors. In conclusion, we found a positive and independent association of serum adiponectin with AAC in male hemodialysis patients, indicating that the reversed association between serum adiponectin and atherosclerosis in patients with CKD dose not result from increased serum adiponectin due to the impaired urinary secretion.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-06850-4