Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis

Blood clot formation inside the membrane oxygenator (MO) remains a risk in extracorporeal membrane oxygenation (ECMO). It is associated with thromboembolic complications and normally detectable only at an advanced stage. Established clinical monitoring techniques lack predictive capabilities, emphas...

Full description

Saved in:
Bibliographic Details
Published in:Biosensors (Basel) 2024-10, Vol.14 (10), p.511
Main Authors: Korte, Jan, Lauwigi, Tobias, Herzog, Lisa, Theißen, Alexander, Suchorski, Kai, Strudthoff, Lasse J, Focke, Jannis, Jansen, Sebastian V, Gries, Thomas, Rossaint, Rolf, Bleilevens, Christian, Winnersbach, Patrick
Format: Article
Language:English
Subjects:
bioimpedance analysis
Biosensing Techniques
Blood
Blood clot
Blood clots
Blood coagulation
clot detection
Complications and side effects
Diagnosis
Early warning systems
ECLS
ECMO
Electric Impedance
Emergency communications systems
Extracorporeal Membrane Oxygenation
Feasibility studies
Fibers
Humans
Impedance, Bioelectric
In vitro methods and tests
membrane oxygenator
Membranes
Monitoring
Monitoring methods
Optical analysis
Oxygenation
Oxygenators
Oxygenators, Membrane
Physiology
Predictions
Risk factors
sensor fibers
Sensors
Surgical apparatus & instruments
Thromboembolism
Thrombosis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood clot formation inside the membrane oxygenator (MO) remains a risk in extracorporeal membrane oxygenation (ECMO). It is associated with thromboembolic complications and normally detectable only at an advanced stage. Established clinical monitoring techniques lack predictive capabilities, emphasizing the need for refinement in MO monitoring towards an early warning system. In this study, an MO was modified by integrating four sensor fibers in the middle of the hollow fiber mat bundle, allowing for bioimpedance measurement within the MO. The modified MO was perfused with human blood in an test circuit until fulminant clot formation. The optical analysis of clot residues on the extracted hollow fibers showed a clot deposition area of 51.88% ± 14.25%. This was detectable via an increased bioimpedance signal with a significant increase 5 min in advance to fulminant clot formation inside the MO, which was monitored by the clinical gold standard (pressure difference across the MO (dp-MO)). This study demonstrates the feasibility of detecting clot growth early and effectively by measuring bioimpedance within an MO using integrated sensor fibers. Thus, bioimpedance may even outperform the clinical gold standard of dp-MO as a monitoring method by providing earlier clot detection.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios14100511