Biological Properties and the Role of IL-25 in Disease Pathogenesis

The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By co...

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Bibliographic Details
Published in:Journal of immunology research 2018-01, Vol.2018 (2018), p.1-8
Main Authors: Bie, Qingli, Shangguan, Guo-Qiang, Shao, Zewei, Liu, Yuwan, Zhang, Bin
Format: Article
Language:English
Subjects:
Allergies
Amino acids
Animals
Asthma
Autoimmune diseases
Autoimmune Diseases - immunology
Biological properties
Bone marrow
Breast cancer
Cytokines
Dermatology
Disease
Drug dosages
Gastric cancer
Graft Rejection - immunology
Humans
Immunology
Inflammation
Interleukin-17 - genetics
Interleukin-17 - immunology
Interleukin-17 - metabolism
Lymphocytes
Lymphocytes T
Molecular Structure
Neoplasms - immunology
Pancreatic cancer
Pathogenesis
Proteins
Psoriasis
Receptors, Interleukin - metabolism
Respiratory tract diseases
Respiratory Tract Diseases - immunology
Review
Signal Transduction
Stem cells
Transcriptome
Tumors
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Summary:The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By contrast, IL-17B is reported to be closely related to certain diseases, particularly tumors such as breast cancer, gastric cancer, and pancreatic cancer. Recently, the biological function of IL-17E (also called IL-25) in disease, particularly airway diseases, has attracted the attention of researchers. However, studies on IL-25 are scant. In this review, we detail the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis.
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/6519465