Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study

subsp. GCL2505 has been shown to have several positive health effects, including improved defecation frequency and reduced visceral fat. It is known that combined intake of GCL2505 and inulin increases the total number of bifidobacteria compared with ingestion of GCL2505 alone. This randomized, doub...

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Bibliographic Details
Published in:Nutrients 2023-12, Vol.15 (24), p.5025
Main Authors: Baba, Yuhei, Saito, Yasuo, Kadowaki, Mei, Azuma, Naoki, Tsuge, Daisuke
Format: Article
Language:English
Subjects:
Abdomen
abdominal fat
Analysis
Bifidobacterium animalis subsp. lactis
Body fat
Body mass index
Cardiovascular disease
Clinical trials
Consent
Diabetes
Ethylenediaminetetraacetic acid
Food
Gastrointestinal surgery
Glucose
gut microbacteria
Hyperlipidemia
Hypertension
inulin
Laxatives
Lipids
Metabolism
Microbiota
Milk
Obesity
Overweight
Prebiotics
Probiotics
synbiotics
Type 2 diabetes
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Summary:subsp. GCL2505 has been shown to have several positive health effects, including improved defecation frequency and reduced visceral fat. It is known that combined intake of GCL2505 and inulin increases the total number of bifidobacteria compared with ingestion of GCL2505 alone. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to confirm that consumption of GCL2505 and inulin reduces abdominal fat ( = 120). Participants consumed a test beverage containing 1 × 10 colony-forming units of GCL2505 per 100 g and 2.0 g of inulin per 100 g for 12 weeks. A change in the visceral fat area (VFA) was set as the primary endpoint. There were significant reductions in VFA and total fat area. The intervention significantly increased the total number of bifidobacteria and affected the levels of several lipid markers. Regression analysis of bifidobacteria and measured parameters showed that total bifidobacteria correlated with VFA and body mass index (BMI), while endogenous bifidobacteria and subsp. correlated only with BMI, suggesting that increases in both contributed to the decrease in VFA. These results suggest that combined intake of GCL2505 and inulin improves the intestinal environment and reduces abdominal fat in association with the SCFA-mediated pathway.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15245025