Prognostic relevance of prognostic nutritional indices in gastric or gastro-esophageal junction cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis

The Prognostic Nutritional Index (PNI) has become an important predictive tool for assessing patients' nutritional status and immune competence. It is widely used in prognostic evaluations for various cancer patients. However, the prognostic relevance of the Prognostic Nutritional Index (PNI) i...

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Published in:Frontiers in immunology 2024-06, Vol.15, p.1382417
Main Authors: Hou, Shufu, Song, Dandan, Hao, Ruiqi, Li, Linchuan, Zhang, Yun, Zhu, Jiankang
Format: Article
Language:English
Subjects:
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - mortality
Esophagogastric Junction - pathology
gastric cancer
gastro-esophageal junction cancer
Humans
immune checkpoint inhibitors
Immune Checkpoint Inhibitors - adverse effects
Immune Checkpoint Inhibitors - therapeutic use
Immunology
meta – analysis
Nutrition Assessment
Nutritional Status
Prognosis
prognostic nutritional index
Stomach Neoplasms - drug therapy
Stomach Neoplasms - immunology
Stomach Neoplasms - mortality
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Summary:The Prognostic Nutritional Index (PNI) has become an important predictive tool for assessing patients' nutritional status and immune competence. It is widely used in prognostic evaluations for various cancer patients. However, the prognostic relevance of the Prognostic Nutritional Index (PNI) in gastric or gastro-esophageal junction cancer patients (GC/GEJC) undergoing immune checkpoint inhibitors (ICIs) treatment remains unclear. This meta-analysis aimed to determine the prognostic impact of PNI in this specific patient cohort. We conducted a thorough literature search, covering prominent databases such as PubMed, Embase, Web of Science, SpringerLink, and the Cochrane Library. The search spanned from the inception of these databases up to December 5, 2023. Employing the 95% confidence interval and Hazard Ratio (HR), the study systematically evaluated the relationship between PNI and key prognostic indicators, including the objective remission rate (ORR), disease control rate (DCR), overall survival (OS) and progression-free survival (PFS) in GC/GEJC patients undergoing ICI treatment. Eight studies comprising 813 eligible patients were selected. With 7 studies consistently demonstrating superior Overall Survival (OS) in the high-Prognostic Nutritional Index (PNI) group compared to their low-PNI counterparts (HR 0.58, 95% CI: 0.47-0.71, P
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1382417