Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population

• Published in: Scientific reports 2022-09, Vol.12 (1), p.16110-16110, Article 16110
• Main Authors: Wang, Xi, Xiao, Lin, Wang, Zhiyuan, Zhi, Liqiang, Li, Qiang
• Format: Article
• Language: English
• Subjects: 692/308/53/2423; 692/499; Arthritis; Cell cycle; Cell differentiation; Cell proliferation; Gene polymorphism; Genotypes; Genotyping; GTP-binding protein; Guanine; Guanine nucleotide-binding protein; Humanities and Social Sciences; Joint diseases; multidisciplinary; Nucleoli; Osteoarthritis; Patients; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Susceptibility
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-20287-4

Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA ( P  = 4.32 × 10 –5 ). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade ( P