Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population

Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribu...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-09, Vol.12 (1), p.16110-16110, Article 16110
Main Authors: Wang, Xi, Xiao, Lin, Wang, Zhiyuan, Zhi, Liqiang, Li, Qiang
Format: Article
Language:English
Subjects:
692/308/53/2423
692/499
Arthritis
Cell cycle
Cell differentiation
Cell proliferation
Gene polymorphism
Genotypes
Genotyping
GTP-binding protein
Guanine
Guanine nucleotide-binding protein
Humanities and Social Sciences
Joint diseases
multidisciplinary
Nucleoli
Osteoarthritis
Patients
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Susceptibility
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3
cites cdi_FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3
container_end_page 16110
container_issue 1
container_start_page 16110
container_title Scientific reports
container_volume 12
creator Wang, Xi
Xiao, Lin
Wang, Zhiyuan
Zhi, Liqiang
Li, Qiang
description Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA ( P  = 4.32 × 10 –5 ). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade ( P  
doi_str_mv 10.1038/s41598-022-20287-4
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_cdb7251f402b4ab4939e80cefa410a29</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_cdb7251f402b4ab4939e80cefa410a29</doaj_id><sourcerecordid>2718494430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3</originalsourceid><addsrcrecordid>eNp9kkFvFSEUhSdGY5vaP-CKxI2bUWBggI2JedG2yYtudE0Y5vKGlxl4AtOk_15806h1IRvI5dwvJyenaV4T_I7gTr7PjHAlW0xpSzGVomXPmkuKGW9pR-nzv94XzXXOR1wPp4oR9bK56HrSCynlZTPv4rLEgO5N8iaUjHxAN1_2HTpAAGRjKMkPa4ERlQlQXrOFU_GDn315QNGhyYQRxVwgmlSm5Is_I25NQLvJB8iATvG0zqb4GF41L5yZM1w_3lfN98-fvu1u2_3Xm7vdx31rORGlmiaES4OFY0JIZzsQVrKBYzBEOefE4AY8Ood760aliBQcFCcd7slIBmm6q-Zu447RHPUp-cWkBx2N1-dBTAdd3Xo7g7bjICgnjmE6MDMw1SmQ2IIzjGBDVWV92FindVhgtFATMfMT6NOf4Cd9iPe6OuJY8Ap4-whI8ccKuejF1xTn2QSIa9ZUEKl6ynlfpW_-kR7jmkKN6qxiirEOVxXdVDbFnBO432YI1r-6obdu6NoNfe6GZnWp25ZyFYcDpD_o_2z9BNhSvBU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2718494430</pqid></control><display><type>article</type><title>Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population</title><source>PubMed (Medline)</source><source>Full-Text Journals in Chemistry (Open access)</source><source>Publicly Available Content (ProQuest)</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Wang, Xi ; Xiao, Lin ; Wang, Zhiyuan ; Zhi, Liqiang ; Li, Qiang</creator><creatorcontrib>Wang, Xi ; Xiao, Lin ; Wang, Zhiyuan ; Zhi, Liqiang ; Li, Qiang</creatorcontrib><description>Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA ( P  = 4.32 × 10 –5 ). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade ( P  &lt; 0.01) and categorized pain scores ( P  &lt; 0.01). Significant eQTL signals for rs11177 on GNL3 in multiple types of human tissues were also identified in GTEx database. Our results have established the link between GNL3 gene and susceptibility of hand OA.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-022-20287-4</identifier><identifier>PMID: 36167888</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/53/2423 ; 692/499 ; Arthritis ; Cell cycle ; Cell differentiation ; Cell proliferation ; Gene polymorphism ; Genotypes ; Genotyping ; GTP-binding protein ; Guanine ; Guanine nucleotide-binding protein ; Humanities and Social Sciences ; Joint diseases ; multidisciplinary ; Nucleoli ; Osteoarthritis ; Patients ; Science ; Science (multidisciplinary) ; Single-nucleotide polymorphism ; Susceptibility</subject><ispartof>Scientific reports, 2022-09, Vol.12 (1), p.16110-16110, Article 16110</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3</citedby><cites>FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2718494430/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2718494430?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids></links><search><creatorcontrib>Wang, Xi</creatorcontrib><creatorcontrib>Xiao, Lin</creatorcontrib><creatorcontrib>Wang, Zhiyuan</creatorcontrib><creatorcontrib>Zhi, Liqiang</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><title>Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA ( P  = 4.32 × 10 –5 ). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade ( P  &lt; 0.01) and categorized pain scores ( P  &lt; 0.01). Significant eQTL signals for rs11177 on GNL3 in multiple types of human tissues were also identified in GTEx database. Our results have established the link between GNL3 gene and susceptibility of hand OA.</description><subject>692/308/53/2423</subject><subject>692/499</subject><subject>Arthritis</subject><subject>Cell cycle</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Gene polymorphism</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>GTP-binding protein</subject><subject>Guanine</subject><subject>Guanine nucleotide-binding protein</subject><subject>Humanities and Social Sciences</subject><subject>Joint diseases</subject><subject>multidisciplinary</subject><subject>Nucleoli</subject><subject>Osteoarthritis</subject><subject>Patients</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><subject>Susceptibility</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kkFvFSEUhSdGY5vaP-CKxI2bUWBggI2JedG2yYtudE0Y5vKGlxl4AtOk_15806h1IRvI5dwvJyenaV4T_I7gTr7PjHAlW0xpSzGVomXPmkuKGW9pR-nzv94XzXXOR1wPp4oR9bK56HrSCynlZTPv4rLEgO5N8iaUjHxAN1_2HTpAAGRjKMkPa4ERlQlQXrOFU_GDn315QNGhyYQRxVwgmlSm5Is_I25NQLvJB8iATvG0zqb4GF41L5yZM1w_3lfN98-fvu1u2_3Xm7vdx31rORGlmiaES4OFY0JIZzsQVrKBYzBEOefE4AY8Ood760aliBQcFCcd7slIBmm6q-Zu447RHPUp-cWkBx2N1-dBTAdd3Xo7g7bjICgnjmE6MDMw1SmQ2IIzjGBDVWV92FindVhgtFATMfMT6NOf4Cd9iPe6OuJY8Ap4-whI8ccKuejF1xTn2QSIa9ZUEKl6ynlfpW_-kR7jmkKN6qxiirEOVxXdVDbFnBO432YI1r-6obdu6NoNfe6GZnWp25ZyFYcDpD_o_2z9BNhSvBU</recordid><startdate>20220927</startdate><enddate>20220927</enddate><creator>Wang, Xi</creator><creator>Xiao, Lin</creator><creator>Wang, Zhiyuan</creator><creator>Zhi, Liqiang</creator><creator>Li, Qiang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220927</creationdate><title>Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population</title><author>Wang, Xi ; Xiao, Lin ; Wang, Zhiyuan ; Zhi, Liqiang ; Li, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/308/53/2423</topic><topic>692/499</topic><topic>Arthritis</topic><topic>Cell cycle</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Gene polymorphism</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>GTP-binding protein</topic><topic>Guanine</topic><topic>Guanine nucleotide-binding protein</topic><topic>Humanities and Social Sciences</topic><topic>Joint diseases</topic><topic>multidisciplinary</topic><topic>Nucleoli</topic><topic>Osteoarthritis</topic><topic>Patients</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><topic>Susceptibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xi</creatorcontrib><creatorcontrib>Xiao, Lin</creatorcontrib><creatorcontrib>Wang, Zhiyuan</creatorcontrib><creatorcontrib>Zhi, Liqiang</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals (Open Access)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xi</au><au>Xiao, Lin</au><au>Wang, Zhiyuan</au><au>Zhi, Liqiang</au><au>Li, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><date>2022-09-27</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>16110</spage><epage>16110</epage><pages>16110-16110</pages><artnum>16110</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 ( GNL3 ) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA ( P  = 4.32 × 10 –5 ). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade ( P  &lt; 0.01) and categorized pain scores ( P  &lt; 0.01). Significant eQTL signals for rs11177 on GNL3 in multiple types of human tissues were also identified in GTEx database. Our results have established the link between GNL3 gene and susceptibility of hand OA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36167888</pmid><doi>10.1038/s41598-022-20287-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2045-2322
ispartof Scientific reports, 2022-09, Vol.12 (1), p.16110-16110, Article 16110
issn 2045-2322
2045-2322
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_cdb7251f402b4ab4939e80cefa410a29
source PubMed (Medline); Full-Text Journals in Chemistry (Open access); Publicly Available Content (ProQuest); Springer Nature - nature.com Journals - Fully Open Access
subjects 692/308/53/2423
692/499
Arthritis
Cell cycle
Cell differentiation
Cell proliferation
Gene polymorphism
Genotypes
Genotyping
GTP-binding protein
Guanine
Guanine nucleotide-binding protein
Humanities and Social Sciences
Joint diseases
multidisciplinary
Nucleoli
Osteoarthritis
Patients
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Susceptibility
title Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A14%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Common%20variants%20in%20GNL3%20gene%20contributed%20the%20susceptibility%20of%20hand%20osteoarthritis%20in%20Han%20Chinese%20population&rft.jtitle=Scientific%20reports&rft.au=Wang,%20Xi&rft.date=2022-09-27&rft.volume=12&rft.issue=1&rft.spage=16110&rft.epage=16110&rft.pages=16110-16110&rft.artnum=16110&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-022-20287-4&rft_dat=%3Cproquest_doaj_%3E2718494430%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c517t-231158a07f4778fc3e7c84b50ea19fff7bfb0dff06cfd991875e9513061d1b8a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2718494430&rft_id=info:pmid/36167888&rfr_iscdi=true