The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart

In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was us...

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Published in:Archives of biological sciences 2011, Vol.63 (3), p.563-569
Main Authors: Nabavi, S.F., Nabavi, S.M., Ebrahimzadeh, M.A., Eslami, Sh, Jafari, N., Moghaddam, Hajizadeh
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Language:English
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Curcumin
enzymatic antioxidant
oxidative stress
sodium fluoride
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description In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured. nema
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subjects Curcumin
enzymatic antioxidant
oxidative stress
sodium fluoride
title The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart
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