Thienopyridine Resistance Among Patients Undergoing Intracoronary Stent Implantation and Treated With Dual Antiplatelet Therapy: Assessment of Some Modifying Factors

In this open, prospective study we assessed the prevalence of antiplatelet resistance among patients subjected to intracoronary stent implantation. In patients treated with aspirin + thienopyridine (N = 32), platelet reactivity index (PRI) significantly decreased after 2 and 7 days of dual antiplate...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2008, Vol.107(4), pp.451-455
Main Authors: Djukanovic, Nina, Todorovic, Zoran, Grdinic, Aleksandra, Vojvodic, Danilo, Prostran, Milica, Ostojic, Miodrag
Format: Article
Language:English
Subjects:
Adult
Aged
antiplatelet agent
Aspirin - pharmacology
Blood Platelets - drug effects
Blood Platelets - metabolism
Clopidogrel
Coronary Vessels - pathology
Coronary Vessels - surgery
Drug Resistance
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Myocardial Ischemia - surgery
Platelet Aggregation Inhibitors - pharmacology
Platelet Function Tests
Prospective Studies
stent
Stents
Ticlopidine - analogs & derivatives
Ticlopidine - pharmacology
Time Factors
vasodilator-stimulated phosphoprotein (VASP) assay
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Summary:In this open, prospective study we assessed the prevalence of antiplatelet resistance among patients subjected to intracoronary stent implantation. In patients treated with aspirin + thienopyridine (N = 32), platelet reactivity index (PRI) significantly decreased after 2 and 7 days of dual antiplatelet treatment in comparison with the same patients on aspirin monotherapy (P
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.08077SC