Acute Eosinophilic Pneumonia Complicated with Venous Thromboembolic Disease—Diagnostic and Therapeutic Considerations

Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse inte...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-06, Vol.12 (6), p.1425
Main Authors: Jankowska, Ewa, Bartoszuk, Iwona, Lewandowska, Katarzyna, Dybowska, Małgorzata, Opoka, Lucyna, Tomkowski, Witold, Szturmowicz, Monika
Format: Article
Language:English
Subjects:
acute eosinophilic pneumonia
Anticoagulants
antithrombin deficiency
Blood
Case Report
Dyspnea
Fever
Laboratories
Lung diseases
Mitochondrial DNA
Oxygen therapy
Pathogenesis
Patients
Pleural effusion
Pneumonia
Proteins
Pulmonary arteries
pulmonary embolism
Pulmonary embolisms
Severe acute respiratory syndrome coronavirus 2
Steroids
Thoracentesis
Thromboembolism
thrombophilia
Thrombosis
Tobacco
Ultrasonic imaging
Veins & arteries
venous thrombosis
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Summary:Acute Eosinophilic Pneumonia (AEP) is a rare idiopathic disease caused by an accumulation of eosinophils in the pulmonary alveoli and interstitial tissue of the lungs. The onset of symptoms is acute; some patients develop respiratory failure. The diagnosis is based on clinical symptoms, diffuse interstitial infiltrates in the lungs on imaging studies, and eosinophilia exceeding 25% on bronchoalveolar lavage or pleural fluid smear. Smokers are primarily at increased risk for the disease. We present a case of venous thromboembolic disease (VTE) that developed in the course of AEP in a previously healthy male smoker. Complete remission of the disease was achieved with anticoagulation therapy combined with a low dose of steroids. Surprisingly, further diagnostics revealed the presence of thrombophilia: antithrombin (AT) deficiency and increased homocysteine level. According to our knowledge, this is the first case of VTE diagnosed in the course of AEP combined with thrombophilia.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12061425