Acute Effects of Breakfast Fruits Meal Sequence and Postprandial Exercise on the Blood Glucose Level and DPP4 Activity among Type 2 Diabetes Mellitus Patients: A Pilot Study

Objectives. Type 2 diabetes mellitus (T2DM) is a major global public health issue. Diet and physical exercise are modifiable factors that influence the glycaemic status of patients with T2DM. We aimed to investigate the acute effects of breakfast fruits meal sequence and postprandial exercise on the...

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Bibliographic Details
Published in:Journal of obesity 2022-09, Vol.2022, p.1-8
Main Authors: Indarto, Dono, Dwipajati, Dwipajati, Dirgahayu, Paramasari, Wibowo, Yohanes Cakrapradipta, Pratama, Yoga Mulia
Format: Article
Language:English
Subjects:
Blood sugar
Carbohydrates
Diabetes
Diabetic retinopathy
Exercise
Food
Fruit
Fruits
Glucose
Health aspects
Investigations
Meals
Mediation
Medical research
Medicine, Experimental
Nutrition research
Physical fitness
Sitagliptin
Type 2 diabetes
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Summary:Objectives. Type 2 diabetes mellitus (T2DM) is a major global public health issue. Diet and physical exercise are modifiable factors that influence the glycaemic status of patients with T2DM. We aimed to investigate the acute effects of breakfast fruits meal sequence and postprandial exercise on the blood glucose level and dipeptidyl peptidase 4 (DPP4) activity among type 2 diabetes mellitus patients. Methods. A randomized pilot study recruited patients with T2DM who attended two primary health care centres in Tasikmadu District, Karanganyar Regency, and Kartasura District, Sukoharjo Regency, Central Java, Indonesia, from July to October 2016. Eligible patients (4 men and 32 women) were randomly divided into four treatment groups. Venous blood samples were analyzed for fasting and one-hour postprandial blood glucose (FBG and 1 h PPG) levels and DPP4 activity. Blood glucose levels were measured using a routine hexokinase method, and serum DPP4 activity was determined spectrophotometrically after incubation with the Gly-Pro-p-nitroanilide substrate. Results. Fruits last meal decreased FBG level whilst fruits first meal did not significantly decrease 1 h PPG level. Both treatments had no acute effects on DPP4 activity but the addition of postprandial exercise helped lower DPP4 activity. Fruit last and first meals showed significant opposite effects on mean changes of FBG level (p
ISSN:2090-0708
2090-0716
DOI:10.1155/2022/4875993