Chemically Bound Resorbable Ceramics as an Antibiotic Delivery System in the Treatment of Purulent–Septic Inflammation of Bone Tissue

• Published in: Ceramics 2022-07, Vol.5 (3), p.330-350
• Main Authors: Lukina, Yuliya, Panov, Yuriy, Panova, Ludmila, Senyagin, Aleksandr, Bionyshev-Abramov, Leonid, Serejnikova, Natalya, Kireynov, Aleksey, Sivkov, Sergey, Gavryushenko, Nikolay, Smolentsev, Dmitriiy, Toshev, Otabek, Lemenovsky, Dmitriy, Krutko, Dmitriy
• Format: Article
• Language: English
• Subjects: Antibacterial agents; antibiotic; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Biomedical materials; Bones; Calcium carbonate; Calcium phosphates; carbonate-substituted hydroxyapatite; Carbonates; Care and treatment; Cement; Ceramic materials; Ceramics; Chemical bonds; Chemically bonded ceramics; consolidation; Diabetes; Drug delivery systems; Drugs; Gram-positive bacteria; Granular materials; Hydroxyapatite; Implantation; Infections; Inflammation; Macroporosity; PEG; Polyethylene glycol; Polyols; Porosity; Potassium; prolonged release; Sodium; System effectiveness; Vancomycin; Vehicles
• ISSN: 2571-6131; 2571-6131
• DOI: 10.3390/ceramics5030026

Local drug delivery systems are an effective approach in the treatment of purulent–septic inflammation of bone tissue. Chemically bonded multiphase ceramics based on calcium-deficient carbonate-substituted hydroxyapatite combine resorbability, osteoconductivity, and the possibility of volumetric incorporation of antibiotics. Macroporosity is regulated by the concentration of polyethylene glycol granules introduced into the initial powder composition, followed by their extraction. The selected conditions for the consolidation of the ceramic matrix and the extraction of PEG granules retain the activity of vancomycin, which is confirmed by the results of microbiological studies. The concentration of vancomycin and the porosity affect the local concentration and release of the antibiotic. The incorporation method provides a prolonged release of the antibiotic for up to 31 days. In vivo experiments with bone implantation have shown that chemically bound macroporous ceramics with incorporated vancomycin are a therapeutically effective carrier of the substance during the healing of bone defects in conditions of surrounding purulent–septic inflammation, and can be considered as a carrier for local antibacterial therapy, at the site of implantation.