Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson’s Disease Patients after Deep Brain Stimulation: A Cohort Study

Objectives. The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent su...

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Published in:Parkinson's disease 2024, Vol.2024, p.3651705-9
Main Authors: Gao, Ying, Wang, Jue, Wang, Linbin, Li, Dianyou, Sun, Bomin, Qiu, Xian
Format: Article
Language:English
Subjects:
Analysis
Attention
Brain
Cognition
Cognition & reasoning
Cohort analysis
Correlation analysis
Deep brain stimulation
Drug dosages
Electrical stimuli
Fatigue
Gender
Hallucinations
Health aspects
Medical research
Medicine, Experimental
Memory
Mental disorders
Mood
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Quality of life
Questionnaires
Regression analysis
Sexual disorders
Sleep
Solitary tract nucleus
Statistical analysis
Subthalamic nucleus
Variance analysis
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Wang, Jue
Wang, Linbin
Li, Dianyou
Sun, Bomin
Qiu, Xian
description Objectives. The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson’s Disease Questionnaire (PDQ-8), respectively. Results. Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P
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The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson’s Disease Questionnaire (PDQ-8), respectively. Results. Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P&lt;0.001) and the preoperative attention/memory subscore (β = −0.154, P=0.026) were predictive of the postsurgery improvement in quality of life (QoL). Conclusion. Deep brain stimulation (DBS) led to an improvement in the patients’ nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients’ quality of life (QoL). Notably, the severity of preoperative attention/memory problems emerged as the most significant predictor of NMS influencing the QoL outcome after STN-DBS at the 1-year follow-up.</description><identifier>ISSN: 2090-8083</identifier><identifier>EISSN: 2042-0080</identifier><identifier>DOI: 10.1155/2024/3651705</identifier><identifier>PMID: 38356939</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Analysis ; Attention ; Brain ; Cognition ; Cognition &amp; reasoning ; Cohort analysis ; Correlation analysis ; Deep brain stimulation ; Drug dosages ; Electrical stimuli ; Fatigue ; Gender ; Hallucinations ; Health aspects ; Medical research ; Medicine, Experimental ; Memory ; Mental disorders ; Mood ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Quality of life ; Questionnaires ; Regression analysis ; Sexual disorders ; Sleep ; Solitary tract nucleus ; Statistical analysis ; Subthalamic nucleus ; Variance analysis</subject><ispartof>Parkinson's disease, 2024, Vol.2024, p.3651705-9</ispartof><rights>Copyright © 2024 Ying Gao et al.</rights><rights>COPYRIGHT 2024 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2024 Ying Gao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2024 Ying Gao et al. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c503t-ccaf3a1dd7e95271854df6159d1ef06e52d2e0a4c8df7513ffd8d39315bfd7b3</cites><orcidid>0000-0002-7510-7940 ; 0009-0008-1816-0367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2928049428/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2928049428?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,25730,27899,27900,27901,36988,36989,44565,53765,53767,75095</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38356939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ahmed, Shiek</contributor><creatorcontrib>Gao, Ying</creatorcontrib><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Wang, Linbin</creatorcontrib><creatorcontrib>Li, Dianyou</creatorcontrib><creatorcontrib>Sun, Bomin</creatorcontrib><creatorcontrib>Qiu, Xian</creatorcontrib><title>Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson’s Disease Patients after Deep Brain Stimulation: A Cohort Study</title><title>Parkinson's disease</title><addtitle>Parkinsons Dis</addtitle><description>Objectives. The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson’s Disease Questionnaire (PDQ-8), respectively. Results. Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P&lt;0.001) and the preoperative attention/memory subscore (β = −0.154, P=0.026) were predictive of the postsurgery improvement in quality of life (QoL). Conclusion. Deep brain stimulation (DBS) led to an improvement in the patients’ nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients’ quality of life (QoL). 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The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson’s Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson’s Disease Questionnaire (PDQ-8), respectively. Results. Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P&lt;0.001) and the preoperative attention/memory subscore (β = −0.154, P=0.026) were predictive of the postsurgery improvement in quality of life (QoL). Conclusion. Deep brain stimulation (DBS) led to an improvement in the patients’ nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients’ quality of life (QoL). Notably, the severity of preoperative attention/memory problems emerged as the most significant predictor of NMS influencing the QoL outcome after STN-DBS at the 1-year follow-up.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>38356939</pmid><doi>10.1155/2024/3651705</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7510-7940</orcidid><orcidid>https://orcid.org/0009-0008-1816-0367</orcidid><oa>free_for_read</oa></addata></record>
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subjects Analysis
Attention
Brain
Cognition
Cognition & reasoning
Cohort analysis
Correlation analysis
Deep brain stimulation
Drug dosages
Electrical stimuli
Fatigue
Gender
Hallucinations
Health aspects
Medical research
Medicine, Experimental
Memory
Mental disorders
Mood
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Quality of life
Questionnaires
Regression analysis
Sexual disorders
Sleep
Solitary tract nucleus
Statistical analysis
Subthalamic nucleus
Variance analysis
title Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson’s Disease Patients after Deep Brain Stimulation: A Cohort Study
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