Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis [version 1; peer review: 1 approved with reservations]

Background: Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an obje...

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Published in:F1000 research 2021, Vol.10, p.508
Main Authors: Goel, Sagar, Kamath, Surendra Umesh, Annappa, Rajendra, Krishnamurthy, Sunil Lakshmipura, Jain, Manesh, Thakkar, Samarth, Damsas, Lulu, Banerjee, Sayak, Divakar, Prajwal Madapura
Format: Article
Language:English
Subjects:
Aged, 80 and over
Cardiovascular disease
Cardiovascular Diseases - complications
Cardiovascular Diseases - epidemiology
Cardiovascular risk factors
Child
Cross-Sectional Studies
Diabetes Mellitus
eng
Heart Disease Risk Factors
Humans
Hypertension
JBS3 risk
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - complications
Osteoarthritis, Knee - epidemiology
Risk Factors
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Summary:Background: Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an objective to investigate their association, screening and management.  Methods: In total, 225 patients were included in this cross-sectional study. Participants were diagnosed with knee OA on the basis of the Kellgren and Lawrence (K-L) classification of their radiograph. Participants were also assessed for CV risk factors (age, body mass index, systolic blood pressure, diabetes mellitus, total cholesterol, high-density lipoprotein, smoking) with the help of the Joint British Society QRisk3 calculator (JBS3), which gave three variables: JBS3 risk score, heart age, and life expectancy. Chi Square, Fishers exact test and one-way ANOVA tests were used to compare the categorical and quantitative variables, respectively. Pearson's correlation coefficient was used to assess the relationship between CV risk factors and knee OA. Results: Patients with severe knee OA had a statistically significantly higher prevalence of CV risk factors (p
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.27744.1