Astaxanthin promotes locomotor function recovery and attenuates tissue damage in rats following spinal cord injury: a systematic review and trial sequential analysis

Spinal cord injury (SCI) is a catastrophic condition with few therapeutic options. Astaxanthin (AST), a natural nutritional supplement with powerful antioxidant activities, is finding its new application in the field of SCI. Here, we performed a systematic review to assess the neurological roles of...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-10, Vol.17, p.1255755-1255755
Main Authors: Zhou, Long-yun, Wu, Zi-ming, Chen, Xu-qing, Yu, Bin-bin, Pan, Meng-xiao, Fang, Lu, Li, Jian, Cui, Xue-jun, Yao, Min, Lu, Xiao
Format: Article
Language:English
Subjects:
astaxanthin
locomotor recovery
Neuroscience
safety
spinal cord injury
systematic review
trial sequential analysis
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Summary:Spinal cord injury (SCI) is a catastrophic condition with few therapeutic options. Astaxanthin (AST), a natural nutritional supplement with powerful antioxidant activities, is finding its new application in the field of SCI. Here, we performed a systematic review to assess the neurological roles of AST in rats following SCI, and assessed the potential for clinical translation. Searches were conducted on PubMed, Embase, Cochrane Library, the Web of Science, China National Knowledge Infrastructure, WanFang data, Vip Journal Integration Platform, and SinoMed databases. Animal studies that evaluated the neurobiological roles of AST in a rat model of SCI were included. A total of 10 articles were included; most of them had moderate-to-high methodological quality, while the overall quality of evidence was not high. Generally, the meta-analyses revealed that rats treated with AST exhibited an increased Basso, Beattie, and Bresnahan (BBB) score compared with the controls, and the weighted mean differences (WMDs) between those two groups showed a gradual upward trend from days 7 (six studies, n = 88, WMD = 2.85, 95% CI = 1.83 to 3.87, p  
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1255755