A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that...

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Bibliographic Details
Published in:Frontiers in pharmacology 2020-02, Vol.11, p.153-153
Main Authors: Luo, Chunxu, Zou, Lin, Sun, Huijun, Peng, Jinyong, Gao, Cong, Bao, Liuchi, Ji, Renpeng, Jin, Yue, Sun, Shuangyong
Format: Article
Language:English
Subjects:
anti-inflammatory
inflammatory diseases
mechanism
Pharmacology
rosmarinic acid
treatment
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Summary:Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The anti-inflammatory effects of RosA have been revealed through and studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the anti-inflammatory effects of RosA in inflammatory diseases and its underlying mechanism.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.00153