A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models

Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is hyperglycemia. Poorly regulated hyperglycemia can damage blood vessel clusters in the kidneys, leading to kidney damage. It...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2023-02, Vol.13 (2), p.560
Main Authors: Putra, I Made Wisnu Adhi, Fakhrudin, Nanang, Nurrochmad, Arief, Wahyuono, Subagus
Format: Article
Language:English
Subjects:
Animal models
Animals
antidiabetic activity
Apoptosis
Blood vessels
Care and treatment
Complications and side effects
Creatinine
Cytotoxicity
Damage
Diabetes
Diabetes mellitus
Diabetic nephropathies
Diagnosis
Drug dosages
Glucose
Glycosylation
Herbal medicine
Hyperglycemia
Insulin resistance
Kidney diseases
Kidneys
Kinases
Medicinal plants
Metabolism
Mortality
Nephropathy
Oxidative stress
Patient outcomes
Patients
phytotherapy
Plant extracts
Proteins
renal
Review
Rodents
Uric acid
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Summary:Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is hyperglycemia. Poorly regulated hyperglycemia can damage blood vessel clusters in the kidneys, leading to kidney damage. Its treatment is difficult and expensive because its causes are extremely complex and poorly understood. Extracts from medicinal plants can be an alternative treatment for DN. The bioactive content in medicinal plants inhibits the progression of DN. This work explores the renoprotective activity and possible mechanisms of various medicinal plant extracts administered to diabetic animal models. Research articles published from 2011 to 2022 were gathered from several databases including PubMed, Scopus, ProQuest, and ScienceDirect to ensure up-to-date findings. Results showed that medicinal plant extracts ameliorated the progression of DN via the reduction in oxidative stress and suppression of inflammation, advanced glycation end-product formation, cell apoptosis, and tissue injury-related protein expression.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13020560