Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

The autoimmune diseases are associated with the host immune system, chronic inflammation, and immune reaction against self-antigens, which leads to the injury and failure of several tissues. The onset of autoimmune diseases is related to unbalanced immune homeostasis. Mesenchymal stem cells (MSCs) a...

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Bibliographic Details
Published in:Stem cell research & therapy 2022-03, Vol.13 (1), p.101-101, Article 101
Main Authors: Jasim, Saade Abdalkareem, Yumashev, Alexei Valerievich, Abdelbasset, Walid Kamal, Margiana, Ria, Markov, Alexander, Suksatan, Wanich, Pineda, Benjamin, Thangavelu, Lakshmi, Ahmadi, Seyed Hossein
Format: Article
Language:English
Subjects:
Arthritis
Autoimmune diseases
Autoimmune Diseases - therapy
B cells
Clinical application
Development and progression
Gastrointestinal diseases
Humans
Immunomodulation
Inflammation
Liver diseases
Lupus
Lupus Erythematosus, Systemic - therapy
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Mesenchymal stromal cell
Review
Rheumatoid factor
Stem cell therapy
Stem cells
Transplantation
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Summary:The autoimmune diseases are associated with the host immune system, chronic inflammation, and immune reaction against self-antigens, which leads to the injury and failure of several tissues. The onset of autoimmune diseases is related to unbalanced immune homeostasis. Mesenchymal stem cells (MSCs) are multipotent cells which have capability to self-renew and differentiate into various cell types that exert a critical role in immunomodulation and regenerative therapy. Under the certain condition in vitro, MSCs are able to differentiate into multiple lineage such as osteoblasts, adipocytes, and neuron-like cells. Consequently, MSCs have a valuable application in cell treatment. Accordingly, in this review we present the last observations of researches on different MSCs and their efficiency and feasibility in the clinical treatment of several autoimmune disorders including rheumatoid arthritis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, autoimmune liver disease, and Sjogren's syndrome.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-02782-7