IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis

• Published in: Mediators of inflammation 2023-04, Vol.2023, p.1265449-11
• Main Authors: Wang, Han-Rui, Wei, Shi-Zhuang, Song, Xiao-Yu, Wang, Yao, Zhang, Wen-Bin, Ren, Chao, Mou, Ya-Kui, Song, Xi-Cheng
• Format: Article
• Language: English
• Subjects: Allergens; Allergic diseases; Allergic rhinitis; Allergies; Animals; Asthma; Cytokines; Dermatitis; Development and progression; Diagnosis; Disease Models, Animal; Dust; Hay fever; Humans; IL-1β; Immunoglobulin E; Inflammation; Inflammatory diseases; Interleukin-1beta; Interleukins; Nose; Pathogenesis; Quality of Life; Review; Rhinitis; Rhinitis, Allergic - therapy; Skin
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2023/1265449

Allergic rhinitis (AR) is a chronic upper airway immune-inflammation response mediated by immunoglobulin E (IgE) to allergens and can seriously affect the quality of life and work efficiency. Previous studies have shown that interleukin-1β (IL-1β) acts as a key cytokine to participate in and promote the occurrence and development of allergic diseases. It has been proposed that IL-1β may be a potential biomarker of AR. However, its definitive role and potential mechanism in AR have not been fully elucidated, and the clinical sample collection and detection methods were inconsistent among different studies, which have limited the use of IL-1β as a clinical diagnosis and treatment marker for AR. This article systematically summarizes the research advances in the roles of IL-1β in allergic diseases, focusing on the changes of IL-1β in AR and the possible interventions. In addition, based on the findings by our team, we provided new insights into the use of IL-1β in AR diagnosis and treatment, in an attempt to further promote the clinical application of IL-1β in AR and other allergic diseases.