Novel MRI‐Based Pedicle Bone Quality Score Independently Predicts Pedicle Screw Loosening after Degenerative Lumbar Fusion Surgery

• Published in: Orthopaedic surgery 2024-10, Vol.16 (10), p.2372-2379
• Main Authors: Li, Qiujiang, Fu, Haiying, Yang, Huiliang, Yang, Xi, Wang, Lei, Song, Yueming
• Format: Article
• Language: English
• Subjects: Back surgery; Body mass index; Bone density; Bone Quality; Clinical; Degenerative disc disease; Demographics; Hounsfield Unit; Magnetic resonance imaging; MRI; Osteoporosis; Patients; Pedicle Bone Quality; Screw Loosening; Surgeons; Tomography; Vertebral Bone Quality
• ISSN: 1757-7853; 1757-7861
• DOI: 10.1111/os.14146

Summary Pedicle screw loosening after posterior lumbar fusion is associated with poor bone quality, which often determines screw pull‐out strength, insertion torque, and vertebral body loading characteristics. Magnetic resonance imaging (MRI)‐based vertebral bone quality (VBQ) score were associated with poor bone quality. Current evidence suggests that pedicle bone quality (PBQ) has a greater impact on screw stability. However, the correlation between MRI‐based PBQ score and screw loosening has not been reported. Purpose To introduce and evaluate an MRI‐based PBQ score to determine its effectiveness in predicting pedicle screw loosening following lumbar fusion surgery. Methods The retrospective study analyzed 244 patients who underwent posterior lumbar interbody fusion (PLIF) with pedicle screws between December 2017 and December 2021, with CT and MRI imaging before surgery. Data collected included patient demographics and preoperative radiological data. Radiographic screw loosening was measured at 12 months postoperatively. Clinical assessments included pain visual analog scale (VAS) and Oswestry Disability Index (ODI) scores. The PBQ score was measured using MRI scans. We use univariate analysis for preliminary screening of the risk factors of screw loosening. Subsequent analysis involved multivariate logistic regression to identify independent predictive factors for screw loosening. We constructed the receiver operating characteristic (ROC) curve to ascertain the discriminative capacity of the PBQ score. The area under the curve (AUC) quantified its predictive accuracy. Additionally, we evaluated the association between PBQ score and screw loosening using Spearman's correlation analysis. Results Overall, 244 patients who underwent PLIF with pedicle screw fixation participated in this study, including 35 in the loosening group and 209 in the non‐loosening group. PBQ score in the loosening group was significantly higher than that in the non‐loosening group. On multivariate logistic regression, the higher PBQ score (OR = 8.481, 95% CI: 3.158–22.774; p