The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19

The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by SARS-CoV, while blood type A individuals have an...

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Bibliographic Details
Published in:Pathophysiology (Amsterdam) 2021-11, Vol.28 (4), p.496-500
Main Authors: Konstantinidis, Theocharis G, Iliadi, Valeria, Martinis, Georges, Panopoulou, Maria
Format: Article
Language:English
Subjects:
blood type
COVID-19
Forssman antigen
Hypothesis
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Summary:The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by SARS-CoV, while blood type A individuals have an increased risk of severe illness. The Forssman antigen, or Forssman glycolipid synthase (FS), was first described in 1911 by John Frederick Forssman. Blood type A/B glycosyltransferases (AT/BTs) and Forssman glycolipid synthase (FS) are encoded by the evolutionarily related ABO (A/B alleles) and genes. In this article, based on published studies about the pathogenesis of the COVID-19, we hypothesize the possible relationship between the COVID-19 infection and rare blood type systems, such as the Forssman antigen system.
ISSN:1873-149X
0928-4680
1873-149X
DOI:10.3390/pathophysiology28040032