Blocking rhinoviral adhesion molecule (ICAM-1): potential to prevent COPD exacerbations

• Published in: International journal of chronic obstructive pulmonary disease 2017-01, Vol.12, p.1413-1414
• Main Authors: Shukla, Shakti Dhar, Hansbro, Philip Michael, Walters, Eugene Haydn
• Format: Article
• Language: English
• Subjects: Acute exacerbations; Asthma; Bacteria; Cell Adhesion Molecules; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Complications and side effects; COPD; Development and progression; Editors; Genetic aspects; Health aspects; Humans; ICAM-1; Intercellular Adhesion Molecule-1; Letter; Mortality; Physiological aspects; Prevention; Pulmonary Disease, Chronic Obstructive; Quality of life; Rhinovirus; Streptococcus infections; Viruses
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S138612

Shakti Dhar Shukla,1–3Philip Michael Hansbro,1–3Eugene Haydn Walters4 1Priority Research Centre for Healthy Lungs, 2School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW, Australia; 3Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; 4School of Medicine, University of Tasmania, Hobart, TAS, Australia Acute exacerbations of COPD (AECOPD) are markers of disease progression and severity, and frequently are used as an outcome variable in interventional studies.1 AECOPD results in increased severity of symptoms and induces disease progression with accelerated decline in lung function and decreased quality of life. The risk of morbidity and mortality is also significantly increased. Most AECOPD (~85%) have an infectious etiology, induced by bacteria and viruses, often rhinovirus (~50%).1 View the original paper by Johnston and colleagues.