Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-03, Vol.21 (6), p.2091
Main Authors: Colpitts, Che C, Tsai, Pei-Ling, Zeisel, Mirjam B
Format: Article
Language:English
Subjects:
Binding sites
cell-to-cell transmission
Chronic infection
endocytosis
fusion
Genomes
Glycoproteins
Heparan sulfate
Hepatitis
Hepatitis C
hepatitis c virus
hepatocyte
Hepatocytes
Human health and pathology
Hépatology and Gastroenterology
Infections
Life Sciences
Lipids
Lipoproteins
Liver
Liver diseases
Medical research
Microbiology and Parasitology
Microscopy
Molecular modelling
Proteins
Researchers
Review
Tropism
Vaccines
viral entry
Viral infections
Virology
Viruses
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Description
Summary:Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21062091