Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia

Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperatu...

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Bibliographic Details
Published in:Applied sciences 2021-07, Vol.11 (14), p.6637
Main Authors: Sanad, Mohamed F., Meneses-Brassea, Bianca P., Blazer, Dawn S., Pourmiri, Shirin, Hadjipanayis, George C., El-Gendy, Ahmed A.
Format: Article
Language:English
Subjects:
Biocompatibility
Cancer therapies
Core-shell particles
core/shell
Crystal structure
Ethanol
Fe/Au nanoparticles
Feasibility
Fever
Gold
Gold coatings
Hyperthermia
Hysteresis loops
Image transmission
Magnetic fields
magnetic nanoparticle hyperthermia
Magnetic properties
Magnetic saturation
Morphology
Nanoparticles
Particle size
Potassium
Room temperature
Scanning electron microscopy
Shells
Spherical shells
superparamagnetic
Transmission electron microscopy
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Summary:Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.
ISSN:2076-3417
2076-3417
DOI:10.3390/app11146637