Design, characterization of Resveratrol-Thermosensitive Hydrogel System (Res-THS) and evaluation of its anti-depressant effect via intranasal administration

• Published in: Materials & design 2022-04, Vol.216, p.110597, Article 110597
• Main Authors: Zhou, Jin-Feng, Duan, LiLi, Wang, Yu-Xin, Wang, Chen-Lin, Tian, Meng-Li, Qi, Xue-Jie, Qiu, Feng
• Format: Article
• Language: English
• Subjects: Anti-depressant; Guanidine-chitosan; Intranasal administration; Resveratrol; Thermosensitive hydrogel
• ISSN: 0264-1275; 1873-4197
• DOI: 10.1016/j.matdes.2022.110597

[Display omitted] •Hydrogel has lower hardness and better safety.•HP-β-CD acts dual functions as hydrogel component and encapsulating resveratrol.•Hydrogel can increase anti-depressant effects of resveratrol. Thermosensitive Hydrogel System (THS) is a suitable candidate for targeted drug delivery, because of its intelligent response and controlled release. In this work, combination of guanidine-chitosan (GCS), β-glycerol phosphate disodium salt (β-GP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) can successfully result in a novel THS by single factor and response surface method. The characterization of THS is detected with gelation temperature, FT-IR, SEM, in vitro release, rheology and biocompatibility. Resveratrol (Res) is selected as a model drug to evaluate the anti-depressant effects of THS loaded Res (Res-THS) via intranasal administration of chronic unpredictable mild stress (CUMS) rats. The results display that the Res-THS can increase concentration of neurotransmitter in rats’ brain tissue via intranasal administration, indicating the anti-depressant effect.