Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography

• Published in: Journal of headache and pain 2018-06, Vol.19 (1), p.43-10, Article 43
• Main Authors: Kamshilin, Alexei A., Volynsky, Maxim A., Khayrutdinova, Olga, Nurkhametova, Dilyara, Babayan, Laura, Amelin, Alexander V., Mamontov, Oleg V., Giniatullin, Rashid
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Blood flow; Calcitonin gene-related peptide; Capillaries; Capsaicin; Capsaicin - pharmacology; Capsaicin receptors; CGRP; Dermal blood flow; Female; Headache; Humans; Internal Medicine; Latent period; Male; Medicine; Medicine & Public Health; Microcirculation; Microcirculation - drug effects; Middle Aged; Migraine; Migraine Disorders - physiopathology; Neurology; Pain Medicine; Perfusion; Photoplethysmography; Research Article; Sensory neurons; Skin; Skin - blood supply; TRPV1; Young Adult
• ISSN: 1129-2369; 1129-2377
• DOI: 10.1186/s10194-018-0872-0

Background The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used. Methods Fourteen migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years) participated in the experiment. A new arrangement of imaging photoplethysmography recently developed by us was used here to discover novel sensitive parameters of dermal blood flow during capsaicin applications in migraine patients. Results Blood pulsation amplitude (BPA) observed as optical-intensity waveform varying synchronously with heartbeat was used for detailed exploration of microcirculatory perfusion induced by capsicum patch application. The BPA signals, once having appeared after certain latent period, were progressively rising until being saturated. Capsaicin-induced high BPA areas were distributed unevenly under the patch, forming “hot spots.” Interestingly the hot spots were much more variable in migraine patients than in the control group. In contrast to BPA, a slow component of waveforms related to the skin redness changed significantly less than BPA highlighting the latter parameter as the potential sensitive biomarker of capsaicin-induced activation of the blood flow. Thus, in migraine patients, there is a non-uniform (both in space and in time) reaction to capsaicin, resulting in highly variable openings of skin capillaries. Conclusion BPA dynamics measured by imaging photoplethysmography could serve as a novel sensitive non-invasive biomarker of migraine-associated changes in microcirculation.