Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder ( Paralichthys olivaceus ) Surimi

There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim...

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Bibliographic Details
Published in:Foods 2020-05, Vol.9 (5), p.647
Main Authors: Oh, Jae-Young, Je, Jun-Geon, Lee, Hyo-Geun, Kim, Eun-A, Kang, Sang In, Lee, Jung-Suck, Jeon, You-Jin
Format: Article
Language:English
Subjects:
AKT protein
Amino acids
Angiotensin
Angiotensin I
Antibodies
antihypertensive
Antihypertensives
Blood pressure
Cardiovascular diseases
Communication
Endothelial cells
Fish
Food
Food science
Functional foods & nutraceuticals
Hypertension
Kinases
Medical research
Molecular weight
Nitric oxide
Nitric-oxide synthase
Oral administration
Paralichthys olivaceus
peptide
Peptides
Peptidyl-dipeptidase A
Phosphorylation
Physiology
Proteins
Risk analysis
Risk factors
Seafood
Studies
Surimi
Umbilical vein
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Summary:There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flounder ( ). Our results show that IVDR, WYK, and VASVI exhibited high Angiotensin I-converting Enzyme (ACE) inhibition activity. These peptides are also shown to increase phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), and significantly promote nitric oxide (NO) production in human umbilical vein endothelial cells. Oral administration of the peptides decreased blood pressure in spontaneously hypertensive rats (SHRs), thereby confirming that the peptides derived from surimi perform antihypertensive activity via the Akt/eNOS pathway. These results indicate that surimi made from contains novel antihypertensive peptides that could be used to enhance the health benefits of food ingredients.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods9050647