Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder ( Paralichthys olivaceus ) Surimi

• Published in: Foods 2020-05, Vol.9 (5), p.647
• Main Authors: Oh, Jae-Young, Je, Jun-Geon, Lee, Hyo-Geun, Kim, Eun-A, Kang, Sang In, Lee, Jung-Suck, Jeon, You-Jin
• Format: Article
• Language: English
• Subjects: AKT protein; Amino acids; Angiotensin; Angiotensin I; Antibodies; antihypertensive; Antihypertensives; Blood pressure; Cardiovascular diseases; Communication; Endothelial cells; Fish; Food; Food science; Functional foods & nutraceuticals; Hypertension; Kinases; Medical research; Molecular weight; Nitric oxide; Nitric-oxide synthase; Oral administration; Paralichthys olivaceus; peptide; Peptides; Peptidyl-dipeptidase A; Phosphorylation; Physiology; Proteins; Risk analysis; Risk factors; Seafood; Studies; Surimi; Umbilical vein
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods9050647

There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flounder ( ). Our results show that IVDR, WYK, and VASVI exhibited high Angiotensin I-converting Enzyme (ACE) inhibition activity. These peptides are also shown to increase phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), and significantly promote nitric oxide (NO) production in human umbilical vein endothelial cells. Oral administration of the peptides decreased blood pressure in spontaneously hypertensive rats (SHRs), thereby confirming that the peptides derived from surimi perform antihypertensive activity via the Akt/eNOS pathway. These results indicate that surimi made from contains novel antihypertensive peptides that could be used to enhance the health benefits of food ingredients.