Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)

Background Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). Methods and Results...

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Published in:Journal of the American Heart Association 2017-11, Vol.6 (11), p.n/a
Main Authors: Rosendaal, Nicole T. A., Alvarado, Beatriz, Wu, Yan Yan, Velez, Maria P., Câmara, Saionara M. Aires, Pirkle, Catherine M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
age at first birth
Age Factors
Aged
Albania - epidemiology
Brazil - epidemiology
Canada - epidemiology
cardiovascular disease risk factors
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Colombia - epidemiology
epidemiology
Female
Framingham Risk Scores
global health
Humans
Original Research
Parity
Parturition
Pregnancy
Pregnancy in Adolescence
Prospective Studies
Risk Factors
Socioeconomic Factors
Young Adult
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cited_by cdi_FETCH-LOGICAL-c5050-fc9e7c748bc8d7ef0e40076765e77414cf4ec66a0c3a0ebfcf967f59eac5aae03
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container_title Journal of the American Heart Association
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creator Rosendaal, Nicole T. A.
Alvarado, Beatriz
Wu, Yan Yan
Velez, Maria P.
Câmara, Saionara M. Aires
Pirkle, Catherine M.
description Background Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). Methods and Results As part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil. FRSs were calculated to describe cardiovascular risk profiles, and linear regression analyses were performed, adjusting for early life and socioeconomic variables. Women with an AFB of
doi_str_mv 10.1161/JAHA.117.007058
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A. ; Alvarado, Beatriz ; Wu, Yan Yan ; Velez, Maria P. ; Câmara, Saionara M. Aires ; Pirkle, Catherine M.</creator><creatorcontrib>Rosendaal, Nicole T. A. ; Alvarado, Beatriz ; Wu, Yan Yan ; Velez, Maria P. ; Câmara, Saionara M. Aires ; Pirkle, Catherine M.</creatorcontrib><description><![CDATA[Background Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). Methods and Results As part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil. FRSs were calculated to describe cardiovascular risk profiles, and linear regression analyses were performed, adjusting for early life and socioeconomic variables. Women with an AFB of <20 years were compared with women with an AFB of 20 to 24, 25 to 29, and ≥30 years, as well as nulliparous women. We also compared FRS between combinations of AFB and parity categories: nulliparous women, parity 1 to 3 combined with AFB <20 years, parity ≥4 with AFB <20 years, parity 1 to 3 with AFB ≥20 years, and parity ≥4 with AFB ≥20 years. Women with an AFB of <20 years had a higher mean FRS compared with all other AFB groups. Compared with the lowest AFB risk group (25–29 years), women with an AFB of <20 years had a 5.8‐point higher mean FRS (95% confidence interval, 3.4–8.3 points). Nulliparous women presented the lowest mean FRS in all analyses. The analysis comparing combinations of AFB and parity categories showed no meaningful differences in FRS between women who had 1 to 3 childbirths and those who had ≥4 childbirths within the stratum of AFB <20 years, and in the stratum of AFB ≥20 years. Conclusions Our analyses suggest that nulliparity and AFB, rather than increasing parity, drive the association with cardiovascular disease risk.]]></description><identifier>ISSN: 2047-9980</identifier><identifier>EISSN: 2047-9980</identifier><identifier>DOI: 10.1161/JAHA.117.007058</identifier><identifier>PMID: 29092844</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adolescent ; Adult ; age at first birth ; Age Factors ; Aged ; Albania - epidemiology ; Brazil - epidemiology ; Canada - epidemiology ; cardiovascular disease risk factors ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Colombia - epidemiology ; epidemiology ; Female ; Framingham Risk Scores ; global health ; Humans ; Original Research ; Parity ; Parturition ; Pregnancy ; Pregnancy in Adolescence ; Prospective Studies ; Risk Factors ; Socioeconomic Factors ; Young Adult</subject><ispartof>Journal of the American Heart Association, 2017-11, Vol.6 (11), p.n/a</ispartof><rights>2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5050-fc9e7c748bc8d7ef0e40076765e77414cf4ec66a0c3a0ebfcf967f59eac5aae03</citedby><cites>FETCH-LOGICAL-c5050-fc9e7c748bc8d7ef0e40076765e77414cf4ec66a0c3a0ebfcf967f59eac5aae03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721784/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721784/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,27924,27925,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29092844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosendaal, Nicole T. A.</creatorcontrib><creatorcontrib>Alvarado, Beatriz</creatorcontrib><creatorcontrib>Wu, Yan Yan</creatorcontrib><creatorcontrib>Velez, Maria P.</creatorcontrib><creatorcontrib>Câmara, Saionara M. Aires</creatorcontrib><creatorcontrib>Pirkle, Catherine M.</creatorcontrib><title>Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)</title><title>Journal of the American Heart Association</title><addtitle>J Am Heart Assoc</addtitle><description><![CDATA[Background Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). Methods and Results As part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil. FRSs were calculated to describe cardiovascular risk profiles, and linear regression analyses were performed, adjusting for early life and socioeconomic variables. Women with an AFB of <20 years were compared with women with an AFB of 20 to 24, 25 to 29, and ≥30 years, as well as nulliparous women. We also compared FRS between combinations of AFB and parity categories: nulliparous women, parity 1 to 3 combined with AFB <20 years, parity ≥4 with AFB <20 years, parity 1 to 3 with AFB ≥20 years, and parity ≥4 with AFB ≥20 years. Women with an AFB of <20 years had a higher mean FRS compared with all other AFB groups. Compared with the lowest AFB risk group (25–29 years), women with an AFB of <20 years had a 5.8‐point higher mean FRS (95% confidence interval, 3.4–8.3 points). Nulliparous women presented the lowest mean FRS in all analyses. The analysis comparing combinations of AFB and parity categories showed no meaningful differences in FRS between women who had 1 to 3 childbirths and those who had ≥4 childbirths within the stratum of AFB <20 years, and in the stratum of AFB ≥20 years. Conclusions Our analyses suggest that nulliparity and AFB, rather than increasing parity, drive the association with cardiovascular disease risk.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>age at first birth</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Albania - epidemiology</subject><subject>Brazil - epidemiology</subject><subject>Canada - epidemiology</subject><subject>cardiovascular disease risk factors</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Colombia - epidemiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>Framingham Risk Scores</subject><subject>global health</subject><subject>Humans</subject><subject>Original Research</subject><subject>Parity</subject><subject>Parturition</subject><subject>Pregnancy</subject><subject>Pregnancy in Adolescence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Young Adult</subject><issn>2047-9980</issn><issn>2047-9980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>DOA</sourceid><recordid>eNqFksFu1DAQhiMEolXpmRvysRy2dRI7Ti5I0ULboFYgFsTRmjjjXRcn3tpJ0b4ST4nTLVV7whfPjH9_Y89MkrxN6WmaFunZ5_qyjpY4pVRQXr5IDjPKxKKqSvryiX2QHIdwQ-MqMpHz6nVykFW0ykrGDpM_decsBoXDSJYbY7vW-HFDmkDqEJwyMGJHfpoYuvAYHU_OPfRmWG-gJ99M-EVWynkMRDtPluA74-4gqMmCJx9NQAhI6t4Na_IV_GiU2cIwBuI0GTdImuumXpGTZojgAUbjBrDk2rXGmnFHzEDqdUxFVuPU7d6_SV5psAGPH_aj5Mf5p-_Ly8XVl4tmWV8tFKecLrSqUCjBylaVnUBNkcX6FKLgKARLmdIMVVEAVTlQbLXSVSE0rxAUB0CaHyXNnts5uJFbb3rwO-nAyPuA82t5_xWLUmGZtq0Q2HHGYg_akiOUuqMzNiaMrA971nZqe-zmMnuwz6DPTwazkWt3J7nIUlGyCDh5AHh3O2EYZW9it6yFAd0UZFrxKs9ykc_Ss71UeReCR_2YJqVyHhg5D0y0hNwPTLzx7unrHvX_xiMK-F7w21jc_Y83-3lWlDT_C1R_z5I</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Rosendaal, Nicole T. A.</creator><creator>Alvarado, Beatriz</creator><creator>Wu, Yan Yan</creator><creator>Velez, Maria P.</creator><creator>Câmara, Saionara M. Aires</creator><creator>Pirkle, Catherine M.</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>201711</creationdate><title>Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)</title><author>Rosendaal, Nicole T. A. ; Alvarado, Beatriz ; Wu, Yan Yan ; Velez, Maria P. ; Câmara, Saionara M. Aires ; Pirkle, Catherine M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5050-fc9e7c748bc8d7ef0e40076765e77414cf4ec66a0c3a0ebfcf967f59eac5aae03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>age at first birth</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Albania - epidemiology</topic><topic>Brazil - epidemiology</topic><topic>Canada - epidemiology</topic><topic>cardiovascular disease risk factors</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Colombia - epidemiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>Framingham Risk Scores</topic><topic>global health</topic><topic>Humans</topic><topic>Original Research</topic><topic>Parity</topic><topic>Parturition</topic><topic>Pregnancy</topic><topic>Pregnancy in Adolescence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosendaal, Nicole T. A.</creatorcontrib><creatorcontrib>Alvarado, Beatriz</creatorcontrib><creatorcontrib>Wu, Yan Yan</creatorcontrib><creatorcontrib>Velez, Maria P.</creatorcontrib><creatorcontrib>Câmara, Saionara M. Aires</creatorcontrib><creatorcontrib>Pirkle, Catherine M.</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the American Heart Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosendaal, Nicole T. A.</au><au>Alvarado, Beatriz</au><au>Wu, Yan Yan</au><au>Velez, Maria P.</au><au>Câmara, Saionara M. Aires</au><au>Pirkle, Catherine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)</atitle><jtitle>Journal of the American Heart Association</jtitle><addtitle>J Am Heart Assoc</addtitle><date>2017-11</date><risdate>2017</risdate><volume>6</volume><issue>11</issue><epage>n/a</epage><issn>2047-9980</issn><eissn>2047-9980</eissn><abstract><![CDATA[Background Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). Methods and Results As part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil. FRSs were calculated to describe cardiovascular risk profiles, and linear regression analyses were performed, adjusting for early life and socioeconomic variables. Women with an AFB of <20 years were compared with women with an AFB of 20 to 24, 25 to 29, and ≥30 years, as well as nulliparous women. We also compared FRS between combinations of AFB and parity categories: nulliparous women, parity 1 to 3 combined with AFB <20 years, parity ≥4 with AFB <20 years, parity 1 to 3 with AFB ≥20 years, and parity ≥4 with AFB ≥20 years. Women with an AFB of <20 years had a higher mean FRS compared with all other AFB groups. Compared with the lowest AFB risk group (25–29 years), women with an AFB of <20 years had a 5.8‐point higher mean FRS (95% confidence interval, 3.4–8.3 points). Nulliparous women presented the lowest mean FRS in all analyses. The analysis comparing combinations of AFB and parity categories showed no meaningful differences in FRS between women who had 1 to 3 childbirths and those who had ≥4 childbirths within the stratum of AFB <20 years, and in the stratum of AFB ≥20 years. Conclusions Our analyses suggest that nulliparity and AFB, rather than increasing parity, drive the association with cardiovascular disease risk.]]></abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>29092844</pmid><doi>10.1161/JAHA.117.007058</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
age at first birth
Age Factors
Aged
Albania - epidemiology
Brazil - epidemiology
Canada - epidemiology
cardiovascular disease risk factors
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Colombia - epidemiology
epidemiology
Female
Framingham Risk Scores
global health
Humans
Original Research
Parity
Parturition
Pregnancy
Pregnancy in Adolescence
Prospective Studies
Risk Factors
Socioeconomic Factors
Young Adult
title Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)
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