The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal isch...

Full description

Saved in:
Bibliographic Details
Published in:Acta cirúrgica brasileira 2013-01, Vol.28 (1), p.5-9
Main Authors: Azevedo, Vera Lucia Fernandes de, Santos, Paulo Sergio Santana, Oliveira Jr, Gildàsio Silveira de, Módolo, Gabriel Pinheiro, Domingues, Maria Aparecida Custódio, Castiglia, Yara Marcondes Machado, Vianna, Pedro Thadeu Galvão, Vane, Luiz Antonio, Módolo, Norma Sueli Pinheiro
Format: Article
Language:English
Subjects:
Acute Kidney Injury
Colloids
Fluid Therapy
Hetastarch
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
ISSN:0102-8650
0102-8650
1678-2674
DOI:10.1590/S0102-86502013000100002