Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

• Published in: Frontiers in physiology 2022-07, Vol.13, p.885185-885185
• Main Authors: Montes-de-Oca-García, Adrián, Corral-Pérez, Juan, Velázquez-Díaz, Daniel, Perez-Bey, Alejandro, Rebollo-Ramos, María, Marín-Galindo, Alberto, Gómez-Gallego, Félix, Calderon-Dominguez, Maria, Casals, Cristina, Ponce-González, Jesús G.
• Format: Article
• Language: English
• Subjects: cardiometabolic risk; caucasian; genetic association studies; healthy lifestyle; metabolism; Physiology; PPARGC1A
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2022.885185

This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass ( p = 0.002), body mass index ( p = 0.024), lean body mass ( p = 0.024), body fat ( p = 0.032), waist circumference ( p = 0.020), and BP recovery ratio ( p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism ( p = 0.045) and total energy expenditure ( p = 0.024). A genotype*sex interaction was found in the QUICKI index ( p = 0.016), with differences between CC and CT/TT in men ( p = 0.049) and between men and women inside the CT/TT group ( p = 0.049). Thus, the PPARGC1A gene rs8192678 C>T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.