Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis

Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNA...

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Published in:Frontiers in immunology 2018-04, Vol.9, p.640-640
Main Authors: Nunes, Sara, Silva, Icaro Bonyek, Ampuero, Mariana Rosa, de Noronha, Almério Libório Lopes, de Souza, Lígia Correia Lima, Correia, Thaizza Cavalcante, Khouri, Ricardo, Boaventura, Viviane Sampaio, Barral, Aldina, Ramos, Pablo Ivan Pereira, Brodskyn, Cláudia, Oliveira, Pablo Rafael Silveira, Tavares, Natalia Machado
Format: Article
Language:English
Subjects:
Biomarkers, Pharmacological
CD40 Antigens - genetics
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
human leishmaniasis
Humans
Immunology
Leishmania braziliensis
Leishmania braziliensis - physiology
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - genetics
microRNA
MicroRNAs - genetics
Receptors, Tumor Necrosis Factor, Type I - genetics
skin
Skin Physiological Phenomena - genetics
transcriptome
Treatment Outcome
TREM-1
Triggering Receptor Expressed on Myeloid Cells-1 - genetics
Wound Healing - genetics
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Summary:Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by validation. Initial analysis highlighted that miRNA expression is altered during LCL, as patients clustered separately from controls. Joint analysis identified eight high confidence miRNAs that had altered expression (-1.5 ≤ fold change ≥ 1.5;  
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.00640