Antioxidative effect of astragalosides on acute pancreatitis in mice

• Published in: Frontiers in veterinary science 2024-07, Vol.11, p.1418899
• Main Authors: Hou, Xueting, Yu, Miao, Xu, Yang, Wang, Liuwei, Chen, Yishan, Tao, Ruisong, Zhang, Qixin, Zhu, Yong
• Format: Article
• Language: English
• Subjects: acute pancreatitis; antioxidative effect; astragalosides; mice; Veterinary Science
• ISSN: 2297-1769; 2297-1769
• DOI: 10.3389/fvets.2024.1418899

The research examined the antioxidative impact of astragalosides (AST) on experimental acute pancreatitis (AP) in mice. This study aims to assess the correlation between varying doses of astragalosides and superoxide dismutase (SOD) activity in an acute pancreatitis mouse model. By examining the interplay between astragaloside's protective effects and its antioxidant properties, we aim to deepen our understanding of its therapeutic potential in acute pancreatitis. The AP model in mice was induced by retrograde injection of sodium deoxycholate into the biliary and pancreatic ducts. Serum amylase activity was monitored at various time points following induction. Furthermore, 24 hours post-induction, levels of serum nitric oxide (NO), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) content in pancreatic tissue were assessed. The findings of this study illustrated that AST, while exhibiting a protective effect in experimental AP, could effectively lower the elevated serum NO levels, reduce MDA production, and enhance SOD activity in model mice. AST notably reduced MDA levels in the pancreatic tissue of AP mice, underscoring its ability to inhibit membrane peroxidation induced by oxygen free radicals. Furthermore, AST was observed to elevate SOD activity in scavenging oxygen free radicals in pancreatic tissue. These findings suggest that AST enhances recovery in an experimental acute pancreatitis mouse model by exerting antioxidative effects.