Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications

The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spr...

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Bibliographic Details
Published in:Biosensors (Basel) 2024-03, Vol.14 (3), p.146
Main Authors: Park, Ki Sung, Park, Tae-In, Lee, Jae Eon, Hwang, Seo-Yeong, Choi, Anna, Pack, Seung Pil
Format: Article
Language:English
Subjects:
Antibodies
Antigens
aptamer
Aptamers
Aptamers, Nucleotide
Bioelectricity
bioprobe
Biosensing Techniques
biosensing technology
Biosensors
Control systems
Coronaviruses
COVID-19
COVID-19 diagnostic tests
COVID-19 Testing
Disease transmission
Efficiency
Genomes
Health aspects
Humans
Infections
infectious disease diagnosis
Infectious diseases
Ligands
Nanobodies
nanobody
Nanomaterials
Nanomedicine
Nucleic acid aptamers
Pandemics
Proteins
Respiratory diseases
Review
SARS-CoV-2
Sensitivity enhancement
Severe acute respiratory syndrome coronavirus 2
Single-Domain Antibodies
Structure
System effectiveness
Therapeutic applications
Viral antibodies
Viral diseases
Viral infections
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Summary:The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spread of the virus through early detection using a rapid, accurate, and easy-to-use diagnostic platform. In biosensors that use bioprobes, the binding affinity of molecular recognition elements (MREs) is the primary factor determining the dynamic range of the sensing platform. Furthermore, the sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers and nanobodies recently developed as advanced MREs for SARS-CoV-2 diagnostic and therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials and devices, with promising enhanced sensitivity and specificity. This review offers valuable insights into advancing biosensing technologies for infectious disease diagnosis and treatment using aptamers and nanobodies as new bioprobes.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios14030146