Metoclopramide for analgesia in renal colic: a narrative systematic review

Metoclopramide, a prokinetic antiemetic with activity at multiple receptor types, may be a useful treatment for renal colic pain. This review investigated whether metoclopramide is an effective analgesic in the management of adults with renal colic.Eligible studies were randomised, quasi-randomised...

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Bibliographic Details
Published in:BMC urology 2024-11, Vol.24 (1), p.240-7, Article 240
Main Authors: Tabner, Andrew, Ganesh, Adithan, Hobbs, Lucy, Prasanna Ponna, Nikhil, Reed, Matthew J, Fakis, Apostolos, Toft, Suzanne, Johnson, Graham
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Anticholinergics
Care and treatment
Central nervous system depressants
Clinical trials
Colic
Data collection
Database searching
Emergency
Humans
Internet/Web search services
Kidneys
Medical research
Medicine, Experimental
Meta-analysis
Metoclopramide
Metoclopramide - therapeutic use
Motility
Narcotics
Nephrolithiasis
Online searching
Pain
Pain perception
Patients
Renal colic
Renal Colic - drug therapy
Systematic review
Vomiting
Web portals
Citations: Items that this one cites
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Summary:Metoclopramide, a prokinetic antiemetic with activity at multiple receptor types, may be a useful treatment for renal colic pain. This review investigated whether metoclopramide is an effective analgesic in the management of adults with renal colic.Eligible studies were randomised, quasi-randomised or case-control trials of metoclopramide for the management renal colic pain. Electronic database searches were performed in November 2022. Screening was performed by two authors independently; disagreement was resolved by discussion or by adjudication by a third author. The Cochrane Collaboration Risk of Bias Tool v2.0 was used to assess bias.Two studies were included, enrolling 279 patients. Heterogeneity of primary outcome measurement and comparators rendered meta-analysis inappropriate; a narrative review is presented. Both studies showed some evidence of analgesic effect. The largest study had a low risk of bias in all assessed domains, whilst the smaller study was at a high risk of bias.There is limited evidence that metoclopramide may be an effective analgesic in the management of renal colic, with the highest quality study demonstrating analgesic properties similar to an intravenous non-steroidal anti-inflammatory medication.Protocol registration Prospero (CRD42022346618).
ISSN:1471-2490
1471-2490
DOI:10.1186/s12894-024-01598-2