Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness

Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome...

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Bibliographic Details
Published in:Metabolites 2018-10, Vol.8 (4), p.62
Main Authors: Ilias, Ioannis, Apollonatou, Sofia, Nikitas, Nikitas, Theodorakopoulou, Maria, Vassiliou, Alice G, Kotanidou, Anastasia, Dimopoulou, Ioanna
Format: Article
Language:English
Subjects:
Adipose tissue
Blood levels
Body fat
Catheters
Cytokines
Energy metabolism
Glucose
Glycerol
Illnesses
Infections
intensive care unit
Interleukin 10
Interleukin 6
Interleukin 8
Ischemia
lactate clearance
Lactic acid
Metabolism
Metabolites
Microdialysis
Mitochondria
Patients
Pyruvic acid
Sepsis
tissue ischemia
Tumor necrosis factor-α
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Summary:Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio >30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio >30 and pyruvate
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo8040062